Animal and Plant Proteins and Glucose Metabolism
The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma
| Condition(s) | Metabolic Syndrome, Metabolic Syndrome, Protection Against, Glucose Metabolism Disorders |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction. |
| Who can participate | Inclusion Criteria: * age: ≥21 and ≤70 years; * BMI: \>24.5 and \<32.5 kg/m2; * habitual protein intake \<0.9 g/kg/day (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and * weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise/week) for at least 2 months before entering the study. Exclusion Criteria: * prediabetes or type 2 diabetes; * evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate \<60 ml/min/1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg/g); * vegetarians or vegans; * intolerance or allergies to ingredients in the metabolic meal or intervention diet; * take dietary supplements (e.g., pre- and probiotics, fiber, fish oil) or medications known to affect our study outcom |
| Ages | 21 Years to 70 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Missouri-Columbia |
| Locations | Columbia, Missouri, United States |
| Start date | 2019-07-12 |
| NCT ID | NCT03994367 |
| Official listing | https://clinicaltrials.gov/study/NCT03994367 |