Approach-Avoidance and Alcohol Challenge Study in PTSD
Individuals with posttraumatic stress disorder (PTSD) have greater prevalence of alcohol use disorders (AUDs), with this comorbidity associated with worse illness outcomes, yet there remains limited mechanistic understanding of how PTSD confers risk for AUD. Understanding risk factors that associate with and predict th
| Condition(s) | Post-Traumatic Stress Disorder, Alcohol Drinking |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Individuals with posttraumatic stress disorder (PTSD) have greater prevalence of alcohol use disorders (AUDs), with this comorbidity associated with worse illness outcomes, yet there remains limited mechanistic understanding of how PTSD confers risk for AUD. Understanding risk factors that associate with and predict the development of AUDs in PTSD could inform interventions and prevention efforts to reduce the rate of this comorbidity and improve outcomes of both disorders. Identifying predictors of risk requires longitudinal studies in PTSD aimed at capturing the mechanisms leading to the emergence of AUDs. There is growing evidence PTSD is related to biased decision-making during approach-avoidance conflict. Alcohol is also suggested to alter approach-avoidance decision-making. AUDs and |
| Who can participate | 1. Inclusion criteria for all participants: * between 21 and 60 years of age * having consumed at least 4 (men) or 3 (women) drinks on at least two occasions over the last year 2. Inclusion criteria for PTSD participants: \- Meeting diagnostic criteria for PTSD, confirmed by structured interview 3. For all subjects exclusion criteria include: * history of significant medical illness, particularly if possible changes in cerebral tissue * neurologic abnormality including significant head trauma (loss of consciousness of ≥5-min) * full Scale IQ \<85 * contraindication to MRI scanning * positive pregnancy test * severe alcohol use disorder * current severe cannabis use disorder * any current substance use disorder (other than alcohol, cannabis, or nicotine) * scores \> 15 on the alcohol Use Di |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Texas at Austin |
| Locations | Austin, Texas, United States |
| Start date | 2023-10-23 |
| NCT ID | NCT06002633 |
| Official listing | https://clinicaltrials.gov/study/NCT06002633 |