Assessment Metabolic Flexibility in Middle-aged Individuals: The Nutritional Impact of Che
The aim of the study will be to evaluate the impact of consumption of meat and dairy products from extensive or intensive farming on apparently healthy individuals aged between 45 and 65 years, a stage of life associated with reduced metabolic flexibility and changes in lipid metabolism. The study will analyze: 1. The
| Condition(s) | Metabolism, Nutrition |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The aim of the study will be to evaluate the impact of consumption of meat and dairy products from extensive or intensive farming on apparently healthy individuals aged between 45 and 65 years, a stage of life associated with reduced metabolic flexibility and changes in lipid metabolism. The study will analyze: 1. The transcription factor PPAR-α determined by the gene expression of PPAR-α in white blood cells, variations in circulating fatty acid metabolism, and the endocannabinoid system determined by circulating analysis of N-acylethanolamine (NAE), and 2-monoacylglycerols (2-MG); 2. Metabolic flexibility, determined by indirect calorimetry in fasting condition during an incremental exercise; 3. Body composition, determined by bioimpedance analysis, waist circumference, and waist-to-hip |
| Who can participate | Inclusion Criteria: * 45-65 years of age * BMI \< 27 * waist-to-hip ratio female\<0.85; male \< 0.98 Exclusion Criteria: * metabolic diseases * Physical activity of competitive nature * Vegans and vegetarians * Intolerances and allergies to the foods under study |
| Ages | 45 Years to 65 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Cagliari |
| Locations | Monserrato, Cagliari, Italy |
| Start date | 2022-01-20 |
| NCT ID | NCT06012227 |
| Official listing | https://clinicaltrials.gov/study/NCT06012227 |