Assessment of Circuit Rebreathing During CPAP Therapy
The goal of this research is to better understand how different CPAP mask designs affect airflow and rebreathing of exhaled carbon dioxide (CO₂) during sleep in individuals with obstructive sleep apnea (OSA).
| Condition(s) | Obstructive Sleep Apnea (OSA) |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The goal of this research is to better understand how different CPAP mask designs affect airflow and rebreathing of exhaled carbon dioxide (CO₂) during sleep in individuals with obstructive sleep apnea (OSA). |
| Who can participate | Inclusion Criteria: * Moderate to severe OSA (AHI\>20) * Self-reported CPAP users or have previously used CPAP * Self-reported holding pressure of maximum 13 cmH2O (if known) * Age: 21-70 * BMI: 18-40 kg/m2 Exclusion Criteria: * Self-reported severe mouth-breathing * Requirement for nocturnal supplemental oxygen or other ventilatory support * Severe cardiovascular or pulmonary disease * Any unstable or acute medical condition * Any additional sleep disorder, including insomnia, except for OSA. |
| Ages | 21 Years to 70 Years |
| Sex | All |
| Lead sponsor | Brigham and Women's Hospital |
| Locations | Boston, Massachusetts, United States |
| Start date | 2025-05-27 |
| NCT ID | NCT07062770 |
| Official listing | https://clinicaltrials.gov/study/NCT07062770 |