ATENEA Study: Adherence to Creatine-Based Nutritional Supplementation in Estrogen-Depleted
This is a prospective, multicenter, observational clinical study conducted under routine clinical practice conditions aimed at describing adherence to a creatine-based nutritional supplement (Creaticare FEM) in estrogen-depleted adult women. Participants will receive the supplement for 12 weeks, and adherence will be a
| Condition(s) | Menopause, Estrogen Deficiency |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This is a prospective, multicenter, observational clinical study conducted under routine clinical practice conditions aimed at describing adherence to a creatine-based nutritional supplement (Creaticare FEM) in estrogen-depleted adult women. Participants will receive the supplement for 12 weeks, and adherence will be assessed as the percentage of doses consumed and the proportion of participants achieving ≥80% adherence. Secondary outcomes include persistence, satisfaction, tolerability, and adherence to recommended physical activity. Exploratory outcomes include changes in muscle strength, body composition, quality of life, joint pain, and skin health. |
| Who can participate | Inclusion Criteria: * Biological female sex. * Age ≥40 years. * Estrogen-depleted status, defined as at least one of the following: natural menopause, defined as amenorrhea for ≥12 consecutive months; surgically induced menopause; late perimenopause with elevated FSH according to clinical judgment. * Absence of major comorbidities that would contraindicate use of the nutritional supplement or the recommended physical activity. * No relevant changes in usual treatment during the previous 3 months. * Ability to understand the study information and provide written informed consent. * Willingness to take the nutritional supplement according to the study instructions. * Willingness to follow general physical activity recommendations provided by the investigator. * Willingness and ability to att |
| Ages | 40 Years to 75 Years |
| Sex | Female |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Margan Biotech |
| Locations | Madrid, Madrid, Spain; Madrid, Madrid, Spain; Madrid, Madrid, Spain; Málaga, Málaga, Spain |
| Start date | 2026-03-20 |
| NCT ID | NCT07580846 |
| Official listing | https://clinicaltrials.gov/study/NCT07580846 |