Autopsy and Photon Counting Computed Tomography to Evaluate Thromboses Related to Central
Central venous (CVC) is essential in modern healthcare but unfortunately associated with complications, including thrombosis. In a recently published study, it was showed that 12 out of 12 deceased patients had subclinical CVK-related thrombosis (Rockholt et al.). To shed light on this problem, the current studies were
| Condition(s) | Central Venous Catheter Thrombosis |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Central venous (CVC) is essential in modern healthcare but unfortunately associated with complications, including thrombosis. In a recently published study, it was showed that 12 out of 12 deceased patients had subclinical CVK-related thrombosis (Rockholt et al.). To shed light on this problem, the current studies were designed. In sub-study 1, deceased patients with CVC who are referred for clinical autopsy are included. Before the autopsy, the deceased will be examined with a photon-counting computed tomography (CT) scan and the results will be compared. In sub-study 2, living patients with CVC who are referred for various CT scans without contrast, are included. After informed consent, the patient will be examined with the photon-counting CT, whose reliability has been validated in Part |
| Who can participate | Substudy 1 Inclusion Criteria: * Diseased patients with an indwelling central venous catheter and a clinical indication for autopsy * Informed and signed consent from next of kind Exclusion Criteria: * None Substudy 2 Inclusion Criteria * Living patients with an indwelling central venous catheter who are referred to a CT scan without iv contrast * Informed and signed consent from the patient Exclusion Criteria \- GFR \<15 mL/min/1.73 m2 |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Thomas Kander |
| Locations | Lund, Skåne County, Sweden |
| Start date | 2025-01-16 |
| NCT ID | NCT06417541 |
| Official listing | https://clinicaltrials.gov/study/NCT06417541 |