B Cell Functions in Periodontitis
The inflammatory response involves many players from the immune response, including B lymphocytes. These cells are responsible for the synthesis of immunoglobulins in response to the presence of an antigen. They are characteristic of chronic inflammation. There are several subsets of B cells characterized by specific m
| Condition(s) | Chronic Periodontitis, Aggressive Periodontitis |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The inflammatory response involves many players from the immune response, including B lymphocytes. These cells are responsible for the synthesis of immunoglobulins in response to the presence of an antigen. They are characteristic of chronic inflammation. There are several subsets of B cells characterized by specific membrane markers. Once activated, these cells express many factors contributing to tissue destruction seen in periodontitis and particularly in osteoclastogenesis (receptor activator of nuclear factor kappa-B ligand, tumor necrosis factor, interleukin-6, macrophage inflammatory protein-1α and Monocyte Chemoattractant Protein-3). During the establishment of a periodontal disease, an important inflammatory infiltrate is observed in the gum. This infiltrate is characterized by th |
| Who can participate | Inclusion Criteria: * Requiring periodontal surgery * In good health * Having signed consent Exclusion Criteria: * Minor * Patient having taken antibiotics in the previous 3 months * Patients with systemic diseases including chronic inflammatory disease * Pregnancy * orthodontic treatment ongoing |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University Hospital, Brest |
| Locations | Brest, France |
| Start date | 2015-05-01 |
| NCT ID | NCT02833285 |
| Official listing | https://clinicaltrials.gov/study/NCT02833285 |