Bioelectrical Impedance Analysis for Perioperative Fluid Evaluation in Colorectal Cancer S
Sarcopenia is a complex syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. In patients with cancer, sarcopenia is associated with poorer prognosis, increased treatment-related toxicity, higher postoperative complication rates, reduced response to therapy, and decreased qual
| Condition(s) | Gastrointestinal Cancer, Digestive System Neoplasms |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Sarcopenia is a complex syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. In patients with cancer, sarcopenia is associated with poorer prognosis, increased treatment-related toxicity, higher postoperative complication rates, reduced response to therapy, and decreased quality of life. Importantly, sarcopenia may be present even in patients with preserved nutritional status or overweight. Patients with gastrointestinal cancers are at particularly high risk of developing sarcopenia, both as a consequence of the malignant disease itself and as a result of systemic anticancer treatment. Early identification of patients at risk is therefore essential in order to enable timely nutritional and supportive interventions. The aim of this study is to eva |
| Who can participate | Inclusion Criteria: Adult patients (≥18 years of age). Histologically confirmed head and neck cancer. Indication for induction chemotherapy followed by chemoradiotherapy with cetuximab. Adequate organ function as required by the study protocol. Ability to provide informed consent. Exclusion Criteria: * Prior systemic therapy or radiotherapy for head and neck cancer. Presence of uncontrolled comorbidities that would preclude study treatment. Known hypersensitivity to cetuximab or components of the treatment regimen. Pregnancy or breastfeeding. |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Institute of Oncology Ljubljana |
| Locations | Ljubljana, Slovenia |
| Start date | 2023-10-24 |
| NCT ID | NCT07404527 |
| Official listing | https://clinicaltrials.gov/study/NCT07404527 |