Biomechanical and Microstructural Properties of Ascending Aortic Aneurysms
An aortic aneurysm (thoracic or abdominal) is a permanent dilatation of the aorta caused by weakening in the arterial wall. The feared complication is aortic rupture or dissection, leading to potentially lethal aortic bleeding and associated with mortality rates up to 95%. The current diagnosis criteria do not suffice,
| Condition(s) | Thoracic Aortic Aneurysms |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | An aortic aneurysm (thoracic or abdominal) is a permanent dilatation of the aorta caused by weakening in the arterial wall. The feared complication is aortic rupture or dissection, leading to potentially lethal aortic bleeding and associated with mortality rates up to 95%. The current diagnosis criteria do not suffice, therefore the goal of this study is the development of an improved biomechanics-based and microstructural-based diagnostic tool. |
| Who can participate | Inclusion Criteria: * Patients suffering from thoracic aortic aneurysms (ATAA), asymptomatic or symptomatic. * Patients with ruptured ATAA undergoing an emergency surgery. * Signed informed consent. Exclusion Criteria: * Patients with ruptured ATAA due to trauma. * The presence of any aneurysm feature that will prevent the collection of tissue samples suitable for the biomechanical and microstructural studies. |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Universitaire Ziekenhuizen KU Leuven |
| Locations | Leuven, Vlaams Brabant, Belgium |
| Start date | 2017-01 |
| NCT ID | NCT03142074 |
| Official listing | https://clinicaltrials.gov/study/NCT03142074 |