Bone, Exercise, Alendronate, and Caloric Restriction
The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight. Participation in this research will involve up to nine assessment visits and last up to two years.
| Condition(s) | Bone Loss |
|---|---|
| Status | Recruiting |
| Phase | Phase 4 |
| Study type | Interventional |
| Summary | The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight. Participation in this research will involve up to nine assessment visits and last up to two years. |
| Who can participate | Inclusion Criteria: * Community-dwelling * BMI\>30 kg/m\^2 or BMI 25.0 to \<30 kg/m\^2 plus one risk factor * Currently receiving routine (annual) dental care * Pre-existing low bone mass (T-score ≤-1.1 to \>-2.5 at the hip, femoral neck, or lumbar spine (L1-L4)) Exclusion Criteria: * Weight greater than 450 lbs (DXA limit) * Resides with someone who is currently participating in BEACON * Dependent on quad cane or walker; inability to walk independently * History of mild cognitive impairment or dementia or evidence of cognitive impairment ((score \<20) on Montreal Cognitive Assessment (MoCA)) * Excessive alcohol use (\>21 drinks/week) in the past month; any non-cannabis illicit drug use * Weight change ≥5% in past 3 months * Regular participation (\>60 mins per day on \> 3 days/week) in st |
| Ages | 60 Years |
| Sex | All |
| Lead sponsor | Wake Forest University Health Sciences |
| Locations | Aurora, Colorado, United States; Winston-Salem, North Carolina, United States |
| Start date | 2023-06-08 |
| NCT ID | NCT05764733 |
| Official listing | https://clinicaltrials.gov/study/NCT05764733 |