Brain Imaging of Cognition Inn Schizophrenia and Depression
Schizophrenia and depression are among the most disabling disorders in all of medicine. Cognitive deficits play a key role in patients' disability, affecting their capacity to contribute actively to society by sustaining employment or academic activity. Moreover, cognitive difficulties tend to persist even after the st
| Condition(s) | Schizophrenia / Schizoaffective Disorder, Depression / Major Depressive Disorder |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Schizophrenia and depression are among the most disabling disorders in all of medicine. Cognitive deficits play a key role in patients' disability, affecting their capacity to contribute actively to society by sustaining employment or academic activity. Moreover, cognitive difficulties tend to persist even after the stabilization of other clinical symptoms. Verbal memory and emotion regulation are two important cognitive domains that are impaired in schizophrenia and depression and are associated with patients' functional outcomes. In this study, brain imaging is used to investigate the brain mechanisms underlying these cognitive deficits in these populations. |
| Who can participate | Inclusion Criteria: * age 18-60 years * current Intelligence Quotient (IQ) \> 70 as measured by the Wechsler Abbreviated Scale of Intelligence (WASI) * the ability to read and speak fluent English * a diagnosis of schizophrenia, schizoaffective or major depression disorder * stable medication for more than one month Exclusion Criteria: * significant neurological or other medical disorders that may produce cognitive impairment * a recent history of substance abuse or dependence (within the past 3 months) * any magnetic resonance imaging (MRI) contraindications (e.g. metallic head implant, history of seizure, pacemaker) * decisional incapacity requiring a guardian * taking medications that are rated as Anticholinergic Burden (ACB) Score 3 (severe) or taking benzodiazepines on a daily basis * |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Lead sponsor | The Royal Ottawa Mental Health Centre |
| Locations | Ottawa, Ontario, Canada |
| Start date | 2019-12-12 |
| NCT ID | NCT04159662 |
| Official listing | https://clinicaltrials.gov/study/NCT04159662 |