Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Vetera
Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain's excitatory/inhibitory (E/I) balance. This pilot project investigates this phenomenon by leveraging electroencephalography (EEG) to measure parietal
| Condition(s) | Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain's excitatory/inhibitory (E/I) balance. This pilot project investigates this phenomenon by leveraging electroencephalography (EEG) to measure parietal lobe alpha rhythms during visual attention tasks. The hypothesis is that targeted visual attention training can modulate these alpha rhythms, improving instrumental activities in daily life. However, outcomes from such training vary, possibly due to individual differences in cortical inhibitory functions. This study will assess the relationship between EEG measures of E/I balance pre- and post-visual attention training and its effects on processing speeds in aging veterans. |
| Who can participate | Inclusion Criteria: Ages: 18-35 (Younger Group); Ages 50-80 (Healthy Older Group); Ages 50-85 (persons with a history of mild traumatic brain injury) * English speaking * Veterans with mild traumatic brain injury (mTBI): * A history of mTBI confirmed by the Ohio State University TBI Identification Method-Short Form (including a requirement that the mTBI caused a loss of consciousness lasting less than 30 min). * An additional note will be made for Veterans with mTBI with a report of objective or subjective cognitive decline not meeting the criteria (i.e.- Montreal Cognitive Assessment (MoCA) \>23) for impairment Exclusion Criteria: Failure to provide informed consent * Metal of foreign objects in the body that would interfere with an magnetic resonance imaging (MRI) or transcranial magneti |
| Ages | 50 Years to 85 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Alabama at Birmingham |
| Locations | Birmingham, Alabama, United States |
| Start date | 2025-07-01 |
| NCT ID | NCT06217575 |
| Official listing | https://clinicaltrials.gov/study/NCT06217575 |