Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)
The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.
| Condition(s) | Coronary Artery Stenosis |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis. |
| Who can participate | Inclusion Criteria: Healthy Participants * Age: \> 40y * No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system. CAD Patients * Age \> 18 y * Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography. Exclusion Criteria: ALL participants: * General MRI contraindications: Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy. * Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam. * Regular nicotine consumption during the last 6 months. Patients only * Vasoactive medication |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre |
| Locations | Montreal, Quebec, Canada |
| Start date | 2019-07-04 |
| NCT ID | NCT04126148 |
| Official listing | https://clinicaltrials.gov/study/NCT04126148 |