Cannabis and Processing Emotions Study
The goal of this study is to test a causal neural mechanism of cannabis use-related problem recognition in individuals with severe cannabis use disorder using a non-invasive form of neuromodulation called transcranial magnetic stimulation (TMS). The main question it aims to answer is: -Does manipulating neural activity
| Condition(s) | Cannabis Use Disorder, Severe |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The goal of this study is to test a causal neural mechanism of cannabis use-related problem recognition in individuals with severe cannabis use disorder using a non-invasive form of neuromodulation called transcranial magnetic stimulation (TMS). The main question it aims to answer is: -Does manipulating neural activity in the medial orbitofrontal cortex of the brain affect cannabis use-related problem recognition? Researchers will compare three forms of theta burst stimulation (TBS; sham, intermittent, and continuous) in each participant to see if manipulations in neural activity lead to changes in cannabis use-related problem recognition. Participants will complete a screening interview about their mental health and substance use history and complete four in-person laboratory sessions, wh |
| Who can participate | Inclusion Criteria: * Meets criteria for current, severe Cannabis Use Disorder (CUD), as assessed by the Structured Clinical Interview (SCID) for the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) during the screening interview * Reports engagement in cannabis use at least four days per week, on average, over the past year * Provide a urine sample positive for tetrahydrocannabinol (THC) * Able to read and write in English * Has used cannabis at least 20 days in the past month * Endorses at least 10 distinct (of 40 possible) cannabis use-related problems across the screening interview and Lab Visit 1 questionnaires Exclusion Criteria: * Other non-cannabis illicit substance use more than once per month, on average, over the past year * Current DSM-5 moderate or se |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Lead sponsor | Auburn University |
| Locations | Auburn, Alabama, United States |
| Start date | 2026-01-22 |
| NCT ID | NCT06907979 |
| Official listing | https://clinicaltrials.gov/study/NCT06907979 |