Cerebello-motor Neuromodulation After Stroke. CERSTIM.
The CERSTIM study is a physiopatholgical study investigating transcranial alternating current stimulation in stroke patients in the cerebello-motor loop. The design is a cross over design testing two frequencies in the gamma band and one placebo. We will use behavioural data, functional MRI, and Electroencephalography
| Condition(s) | Stroke, Healthy |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The CERSTIM study is a physiopatholgical study investigating transcranial alternating current stimulation in stroke patients in the cerebello-motor loop. The design is a cross over design testing two frequencies in the gamma band and one placebo. We will use behavioural data, functional MRI, and Electroencephalography to disentangle the effect of tACS and its frequency. Healthy participants will be also recruited. |
| Who can participate | PATIENTS Inclusion Criteria: * Male or female aged 18 years or older on the day of inclusion. * Affiliated with a social security system, Universal Health Coverage (CMU), or any equivalent scheme. * Ischemic stroke or intraparenchymal hematoma that occurred more than 6 months ago, with no upper time limit. * Motor deficit of the upper limb confirmed by the ARAT scale, with the ability to grip and press on a tablet. * stroke lesion not affecting the motor cortex in the hand knob area. Exclusion Criteria: \-- Pregnant and breastfeeding women * Total paralysis of the affected hand * Conditions that are life-threatening or could compromise follow-up during the study period * Contraindications to MRI and tACS (ferromagnetic surgical clips, ocular implants, intraocular or nervous system metallic |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Institut National de la Santé Et de la Recherche Médicale, France |
| Locations | Paris, France; Toulouse, France |
| Start date | 2024-12-13 |
| NCT ID | NCT06599931 |
| Official listing | https://clinicaltrials.gov/study/NCT06599931 |