Cerebrovascular Health and Resilience in Midlife
This study examines cardiovascular responses to a brief psychological challenge under laboratory conditions among adult volunteers. The study volunteers are asked to complete two study sessions. In one session, the volunteers are asked to provide demographic and health-related information via questionnaires and an inte
| Condition(s) | Psychological Stress, Cardiovascular Diseases, Cerebrovascular Disorders |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study examines cardiovascular responses to a brief psychological challenge under laboratory conditions among adult volunteers. The study volunteers are asked to complete two study sessions. In one session, the volunteers are asked to provide demographic and health-related information via questionnaires and an interview. In that session, volunteers would then be asked to undergo evaluations of their body composition, blood pressure, heart rate, and other signs of cardiovascular function and health. Lastly, volunteers would be asked to take part in a brief and challenging psychological task after a period of rest while cardiovascular activity is measured. In the other session, volunteers are asked to undergo magnetic resonance imaging and to complete neuropsychological tests of memory, |
| Who can participate | Inclusion Criteria: * Able to attend 2 study visits at the University of Pittsburgh campus in Oakland (Pennsylvania) * Able to read and speak English Exclusion Criteria: * Uncontrolled hypertension (systolic blood pressure \>160 or diastolic blood pressure \>100 mmHg) * Current use of anticonvulsant, anti-Parkinson, neuroleptic, or antipsychotic medications * Current use of glucocorticoids (e.g., oral prednisone) or ephedrine * Current chronic conditions of the lungs, liver and kidney, as well as cancer (chemotherapy and radiation) treatment in the past 12 months (allowances are made for non-melanoma skin cancer treatment, controlled asthma, and allergy inhalers) * Self-reported major neurological disorders or brain injuries (e.g., multiple sclerosis, cerebral palsy, major head injury) * S |
| Ages | 40 Years to 59 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Pittsburgh |
| Locations | Pittsburgh, Pennsylvania, United States |
| Start date | 2023-10-17 |
| NCT ID | NCT06029348 |
| Official listing | https://clinicaltrials.gov/study/NCT06029348 |