Cervical Spinal Cord Associative Plasticity
Associative plasticity has been used to promote functional recovery from conditions affecting movement. Prior work from the Carmel laboratory has shown that paired associative stimulation protocols timed to converge in the cervical spinal cord induce significantly larger upper limb motor responses than if timed to conv
| Condition(s) | Cervical Spinal Cord Plasticity |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Associative plasticity has been used to promote functional recovery from conditions affecting movement. Prior work from the Carmel laboratory has shown that paired associative stimulation protocols timed to converge in the cervical spinal cord induce significantly larger upper limb motor responses than if timed to converge in the motor cortex. The goal of this prospective experimental study in typically developing adults is to test the effects of pairing sub-threshold hand motor cortical and median nerve stimulation targeted to induce plasticity in the cervical spinal cord, rather than in the motor cortex. Based on preliminary data, the investigators are performing a confirmatory study to test the physiological and behavioral effects of the paired brain and peripheral nerve protocol, calle |
| Who can participate | Inclusion Criteria: * Willingness to participate in up to 4 sessions * Maintenance of caffeine and exercise levels at time of sessions * Ability to provide informed consent * No known central or peripheral neurological disease or injury * No known musculoskeletal injury of the tested arm or hand Exclusion Criteria: * Personal or family history of seizures * Use of medications that lower seizure threshold * History of implanted equipment including stimulators/pacemakers |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Columbia University |
| Locations | New York, New York, United States |
| Start date | 2026-05-09 |
| NCT ID | NCT07539025 |
| Official listing | https://clinicaltrials.gov/study/NCT07539025 |