Characterization of Exosomes Platelets-released
Extracellular vesicles (EVs) play a key role in cell-to-cell communication. They are small vesicles that contain rich molecular cargo. Recently, they have been proposed as biomarkers for clinical diagnostics. EVs include three classes: small EVs (exosomes), large EVs (microparticles), and apoptotic bodies. Platelet-der
| Condition(s) | Platelet Thrombus |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Extracellular vesicles (EVs) play a key role in cell-to-cell communication. They are small vesicles that contain rich molecular cargo. Recently, they have been proposed as biomarkers for clinical diagnostics. EVs include three classes: small EVs (exosomes), large EVs (microparticles), and apoptotic bodies. Platelet-derived EVs (PEVs) are the most abundant class in human blood and can actively participate in numerous physiological and pathological processes. The information about the role of platelet exosomes in cardiovascular disease and the effect of antiplatelet agents on their release and content is very limited. |
| Who can participate | Inclusion Criteria: * subjects without known pathologies Exclusion Criteria: * individuals with gastrointestinal diseases, * individuals with history of hepatic diseases, * individuals with history of urogenital diseases, * individuals with history of hematological diseases, * individuals with history of immunological diseases, * individuals with history of renal diseases, * individuals with history of metabolic diseases * individuals with history of respiratory diseases * individuals with history of cancer * individuals with history of cardiovascular disease * individuals having permanent organ damage * individuals with major trauma in the last 6 months prior to enrollment * individuals with surgery in the last 6 months prior to enrollment * individuals taking medication in the 15 days pr |
| Ages | 20 Years to 60 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Centro Cardiologico Monzino |
| Locations | Milan, Italy |
| Start date | 2021-07-08 |
| NCT ID | NCT06298682 |
| Official listing | https://clinicaltrials.gov/study/NCT06298682 |