Characterization of Nociception Phenotype in Individuals With Intellectual Disability
Background: People with intellectual disability (ID) often have physical disabilities as well. These physical problems can affect their bones, muscles, nerves, and gastrointestinal tracts. All of these issues can also cause pain. Yet little research has been done on pain in people with ID. Objective: To compare brain r
| Condition(s) | Intellectual Disability |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Background: People with intellectual disability (ID) often have physical disabilities as well. These physical problems can affect their bones, muscles, nerves, and gastrointestinal tracts. All of these issues can also cause pain. Yet little research has been done on pain in people with ID. Objective: To compare brain responses to unpleasant stimuli in people with and without ID. Eligibility: People aged 8 to 30 years diagnosed with an ID. Healthy volunteers without an ID are also needed. Design: The study requires only 1 visit of up to 4 hours. Participants with ID may come for up to 5 shorter visits instead. Participants will take a test to measure their level of ID. They will have a physical exam. Both groups will answer questions about pain and how their bodies react to it. They will an |
| Who can participate | * INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: For All Participants * Provision of signed and dated informed consent form by participant or parent / Legally Authorized Representative (LAR) of patient. * Stated willingness to comply with all study procedures and availability for the duration of the study. * Male or female, aged 8-30 years of age. * Agreement to avoid use of analgesics, NSAIDs, caffeine (24 hours before procedures), illicit substances and alcohol within 2 days prior to enrollment and during study participation. Healthy Adult Controls * IQ above 85. * Must be fluent in the English Language. Healthy Children * IQ above 85. * Must be fluent in the English Language. Patients -Diagnosis of Intelle |
| Ages | 8 Years to 30 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | National Institutes of Health Clinical Center (CC) |
| Locations | Bethesda, Maryland, United States |
| Start date | 2026-03-27 |
| NCT ID | NCT05473429 |
| Official listing | https://clinicaltrials.gov/study/NCT05473429 |