Circadian Misalignment and Energy Balance
Preliminary findings from the investigators' lab suggest that circadian misalignment, occurring when meals and sleep are mistimed from one another, alters resting state neuronal processing in areas relevant to food reward and interoception; supporting a role of sleep and meal misalignment, on energy balance regulation.
| Condition(s) | Obesity |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Preliminary findings from the investigators' lab suggest that circadian misalignment, occurring when meals and sleep are mistimed from one another, alters resting state neuronal processing in areas relevant to food reward and interoception; supporting a role of sleep and meal misalignment, on energy balance regulation. No study has been done to disentangle the effects of sleep and meal timing on body weight regulation, independent of sleep duration. This study will provide information to guide messaging related to timing of meals and sleep that can be translated to individuals whose sleep follows unconventional times, such as shift workers and those with jetlag and social jetlag. |
| Who can participate | Inclusion Criteria: * All racial and ethnic groups * Body mass index 20-34.9 kg/m2 * Average sleep duration ≥7 hour/night, assessed during 2-week screening period * Eat within 1 hour of awakening at least 5 days/week * Midpoint of sleep at 4 AM or earlier Exclusion Criteria: * \<10 nights of sleep \<7 hour during the 2-week screening period * Daytime napping * Current or past sleep disorder (Sleep Disorders Inventory); Insomnia Severity Index Score \>10 * Current or past psychiatric disorder, including eating disorders and seasonal affective disorder * Any psychological or psychiatric disorder deemed to interfere with study outcomes * Smoking (currently smoking any cigarettes or using tobacco products, e-cigarettes and vapes, or ex-smokers \<3 years) * Night and rotating shift work * Trave |
| Ages | 20 Years to 49 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Columbia University |
| Locations | New York, New York, United States |
| Start date | 2019-01-01 |
| NCT ID | NCT03663530 |
| Official listing | https://clinicaltrials.gov/study/NCT03663530 |