Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preserv
For the first time, allografts from human-extracted teeth will be prepared and evaluated in a prospective clinical trial to assess their efficacy for alveolar ridge preservation. The reconstruction and preservation of the alveolar ridge after tooth extraction are essential for future prosthetic rehabilitation. Autogeno
| Condition(s) | Alveolar Ridge Preservation |
|---|---|
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Study type | Interventional |
| Summary | For the first time, allografts from human-extracted teeth will be prepared and evaluated in a prospective clinical trial to assess their efficacy for alveolar ridge preservation. The reconstruction and preservation of the alveolar ridge after tooth extraction are essential for future prosthetic rehabilitation. Autogenous bone grafts, while effective, are limited by donor site morbidity and insufficient graft quantity. Allogenic dentin grafts from healthy human donors present a scalable solution. This study aims to evaluate the biocompatibility and effectiveness of two types of allogenic dentin grafts-demineralized dentin allografts (DDA) and whole tooth allografts (WTA)-for alveolar ridge preservation, contributing to innovative, sustainable dental practices. |
| Who can participate | Inclusion and Exclusion Criteria for Donors: Inclusion Criteria: * Students, interns, or residents willing to participate and provide informed consent. * No history of systemic diseases such as diabetes, hepatitis, or immune disorders. * Negative blood screening for HIV, HBV, and HCV. * Non-smokers or individuals who have not smoked within the last six months. Exclusion Criteria: * History of systemic conditions affecting oral or overall health. * Positive blood tests for communicable diseases. * Active oral infections or untreated dental caries. * Pregnant or lactating individuals. * Individuals with a history of smoking or substance abuse within the last six months. Inclusion and Exclusion Criteria for Recipients: Inclusion Criteria: * Patients aged 18-60 years, requiring extraction of a |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Lead sponsor | Jordan University Hospital |
| Locations | Amman, Jordan |
| Start date | 2025-01-01 |
| NCT ID | NCT06827665 |
| Official listing | https://clinicaltrials.gov/study/NCT06827665 |