Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenou
Stroke is a common cause of disability. The most common type of stroke, an ischemic stroke, is caused by a blood vessel in the brain getting blocked by a clot. When this happens, part of the brain is damaged because it is not getting the blood supply it needs. To treat this type of stroke, doctors give medication and/o
| Condition(s) | Acute Ischemic Stroke |
|---|---|
| Status | Recruiting |
| Phase | Phase 2 |
| Study type | Interventional |
| Summary | Stroke is a common cause of disability. The most common type of stroke, an ischemic stroke, is caused by a blood vessel in the brain getting blocked by a clot. When this happens, part of the brain is damaged because it is not getting the blood supply it needs. To treat this type of stroke, doctors give medication and/or do a procedure to remove the blockage and restore blood supply to the brain. Unfortunately, patients who have had an ischemic stroke are at higher risk of having another ischemic stroke. This risk is highest in the first 21 days after a stroke. Currently, doctors give patients the medication aspirin every day, starting 24 hours after stroke treatment, to prevent recurrent strokes. However, some studies have shown that giving another medication, clopidogrel, in addition to a |
| Who can participate | Inclusion Criteria: 1. Participants must be \>18 years of age at the time of randomization 2. Acute non-cardioembolic ischemic stroke in the anterior circulation treated with reperfusion therapy defined as intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT) 3. Time from end of acute reperfusion therapy to randomization ≤ 24 hours 4. Mild to moderate deficit defined as a National Institute of Health stroke scale of ≤11 at the time of randomization 5. At least one non-contrast CT scan completed post reperfusion therapy and prior to randomization without any hemorrhage (including hemorrhagic infarction) and/or contrast extravasation. 6. Premorbid mRS less than or equal to 2 7. Signed informed consent from the patient or legally authorized representative Exclusion Criteria: 1 |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | University of Alberta |
| Locations | Edmonton, Alberta, Canada |
| Start date | 2025-09-02 |
| NCT ID | NCT06638151 |
| Official listing | https://clinicaltrials.gov/study/NCT06638151 |