CMR-Based Prognostic Study in Patients With Cardiac Implantable Electronic Devices
Cardiac implantable electronic devices (CIEDs) are widely used to treat patients with heart failure, malignant arrhythmias, and other conditions. However, accurately identifying suitable candidates for CIED implantation remains a clinical challenge. Cardiovascular magnetic resonance imaging (CMR) provides a comprehensi
| Condition(s) | Arrhythmias |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Cardiac implantable electronic devices (CIEDs) are widely used to treat patients with heart failure, malignant arrhythmias, and other conditions. However, accurately identifying suitable candidates for CIED implantation remains a clinical challenge. Cardiovascular magnetic resonance imaging (CMR) provides a comprehensive assessment of cardiac structure, function, and tissue characteristics, facilitating evaluation of the myocardial substrate for arrhythmias. This study aims to evaluate the prognostic value of multiparametric CMR-derived imaging markers in CIED patients through preoperative CMR examinations. Imaging parameters of interest include structural-functional indices, myocardial strain, late gadolinium enhancement, entropy, and T1 and T2 mapping. Long-term clinical outcomes will be |
| Who can participate | Inclusion Criteria: 1. Adult patients (≥18 years old). 2. Patients with guideline-based indications for cardiac implantable electronic device (CIED) therapy, including pacemaker, implantable cardioverter-defibrillator, or cardiac resynchronization therapy. 3. Patients who underwent cardiovascular magnetic resonance (CMR) imaging as part of routine clinical evaluation prior to CIED implantation or consideration of CIED therapy. Exclusion Criteria: 1. Patients younger than 18 years of age. 2. Patients with non-diagnostic or poor-quality CMR images that preclude reliable image analysis. 3. Patients with incomplete key clinical data or missing follow-up information for primary outcome assessment. 4. Patients with prior heart transplantation or implantation of ventricular assist devices before |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Chinese Academy of Medical Sciences, Fuwai Hospital |
| Locations | Beijing, China |
| Start date | 2010-01-01 |
| NCT ID | NCT07336225 |
| Official listing | https://clinicaltrials.gov/study/NCT07336225 |