Cognitive Decline Following Deep Brain Stimulation
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSC
| Condition(s) | Parkinson Disease, Movement Disorders |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments. |
| Who can participate | PD Participants Inclusion Criteria: * Subjects above 18 years of age * Subjects who will undergo DBS surgery as part of their clinical care for PD Exclusion Criteria: * Uncorrected visual or hearing impairments, as indicated by self-report * Individuals who are pregnant or expect to become pregnant during the course of the study * Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner * COPD with oxygen dependence * Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.) Non-PD Control Participants Inclusion Criteria: * Subjects above 18 years of age * Age matched to participants in PD group Exclusion Criteria: * Diagnosis of Parkinsons Disease or other movement disorder * Untreated neuropsychiatric disorders * Uncorrected |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Medical University of South Carolina |
| Locations | Charleston, South Carolina, United States |
| Start date | 2023-04-01 |
| NCT ID | NCT05822388 |
| Official listing | https://clinicaltrials.gov/study/NCT05822388 |