Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cro
Migraine is one of the primary headache disorders with a high prevalence worldwide, leading to significant disability and reduced quality of life. Trigeminal nerve activation and alterations in central pain processing mechanisms play a crucial role in the pathophysiology of migraine. Recent studies suggest that migrain
| Condition(s) | Neck Pain, Migraine, Low Back Pain |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Migraine is one of the primary headache disorders with a high prevalence worldwide, leading to significant disability and reduced quality of life. Trigeminal nerve activation and alterations in central pain processing mechanisms play a crucial role in the pathophysiology of migraine. Recent studies suggest that migraine may not only be a headache disorder but also a systemic pain disorder associated with changes in central pain processing mechanisms. Central sensitization is defined as increased sensitivity of nociceptive neurons in the central nervous system to afferent stimuli and is considered a key mechanism in the development and maintenance of chronic pain conditions. This condition is characterized by pain hypersensitivity, allodynia, and generalized pain sensitivity. In addition to |
| Who can participate | Inclusion Criteria: * Being between 18 and 65 years of age, * Being able to read and understand Turkish, * Agreeing to participate voluntarily, * Having an episodic or chronic migraine diagnosis according to the International Classification of Headache Disorders Edition 3 criteria; * Having neck pain and/or lower back pain without any underlying diagnosis accompanying the migraine diagnosis. Exclusion Criteria: * A history of neurological disorder (e.g., Multiple Sclerosis), * Inflammatory rheumatic disorders (e.g., Rheumatoid Arthritis), generalized chronic pain syndromes (e.g., Fibromyalgia), * Any other headache disease, any other systemic disease, * Acute fracture and infection, * Spinal surgery or spinal disease diagnosis within the last 6 months, * Serious musculoskeletal trauma with |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | Bozok University |
| Locations | Gaziantep, Merkez, Turkey (Türkiye) |
| Start date | 2026-04-30 |
| NCT ID | NCT07567300 |
| Official listing | https://clinicaltrials.gov/study/NCT07567300 |