Comparative Study Between Photodynamic Therapy with LED Associated with Probiotics in the
Halitosis is a term that defines any odor or bad smell coming from the oral cavity, which can have a local or systemic origin. This project aims to verify if there is a difference in the effectiveness of treatment with antimicrobial photodynamic therapy (aPDT) with LED associated with treatment using probiotics in redu
| Condition(s) | Halitosis |
|---|---|
| Status | Recruiting |
| Phase | Phase 1 |
| Study type | Interventional |
| Summary | Halitosis is a term that defines any odor or bad smell coming from the oral cavity, which can have a local or systemic origin. This project aims to verify if there is a difference in the effectiveness of treatment with antimicrobial photodynamic therapy (aPDT) with LED associated with treatment using probiotics in reducing halitosis. 92 participants, aged 18 to 60 years, diagnosed with halitosis, presenting sulfhydride (SH2) ≥ 112 ppb in gas chromatography will be selected. Participants will be randomly divided into 4 groups (n=23), which will receive different treatments: Group 1 (control): brushing, dental floss and tongue scraper; Group 2: brushing, dental floss, tongue scraper and aPDT with blue LED and annatto; Group 3: brushing, dental flossing, tongue scraper and aPDT with blue LED, |
| Who can participate | Inclusion Criteria: * Diagnosis of halitosis showing sulfhydride (SH2) ≥ 112 ppb in gas chromatography. Exclusion Criteria: * Individuals with dentofacial anomalies (such as cleft lip, cleft palate and nasopalatine); * Undergoing orthodontic and/or orthopedic treatment; * Undergoing oncological treatment; * With systemic alterations (gastrointestinal, renal, hepatic) * Undergoing antibiotic treatment up to 1 month before the research; * Pregnant women. |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Lead sponsor | University of Nove de Julho |
| Locations | São Paulo, São Paulo, Brazil |
| Start date | 2024-11-01 |
| NCT ID | NCT06583720 |
| Official listing | https://clinicaltrials.gov/study/NCT06583720 |