Comparing a Diagnostic and Treatment Strategy of Upfront CTCA With SOC in Patients With Ch
Rationale: Patients with chest pain usually undergo multiple diagnostic examinations to demonstrate or rule out atherosclerotic coronary artery disease (CAD). In addition to high healthcare costs, some of the examinations do not assess the presence of CAD, which means that patients may be undertreated and are at risk f
| Condition(s) | Chest Pain, CAD |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Rationale: Patients with chest pain usually undergo multiple diagnostic examinations to demonstrate or rule out atherosclerotic coronary artery disease (CAD). In addition to high healthcare costs, some of the examinations do not assess the presence of CAD, which means that patients may be undertreated and are at risk for myocardial infarction. A uniform diagnostic and treatment strategy that uses computed tomography coronary angiography (CTCA) as initial examination may reduce major adverse cardiac events (MACE) and may reduce healthcare costs. In addition, we hypothesize that this strategy improves angina-related health status and reduces the number of invasive coronary angiograms (CAG's). Objectives: * To show that the intervention is non-inferior to the control with regards to clinical |
| Who can participate | Inclusion Criteria: * \>18 years Exclusion Criteria: * Presentation with acute coronary syndrome * Acute coronary syndrome within last 3 months * History of obstructive coronary artery disease on imaging * History of PCI and/or CABG * Severe renal failure * Severe allergy to ionidated contrast medium * Known pregnancy * Patients with an estimated life expectancy of less than 1 year |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
| Locations | Amsterdam, North Holland, Netherlands |
| Start date | 2022-09-14 |
| NCT ID | NCT05344612 |
| Official listing | https://clinicaltrials.gov/study/NCT05344612 |