Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch
This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches. These are patches comprising short microneedles embedded with hydrolysed RNA (siRNAs).
| Condition(s) | Keloid, Wound Heal, Wound |
|---|---|
| Status | Recruiting |
| Phase | Phase 2 |
| Study type | Interventional |
| Summary | This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches. These are patches comprising short microneedles embedded with hydrolysed RNA (siRNAs). |
| Who can participate | Inclusion Criteria: * Adult * Age 21-75 * 2 weeks (+/- 7 days) after surgical operation with incision into the dermis * Post-stitch removal when stitches were applied * Wound closure/union achieved Exclusion Criteria: * Pregnant or lactating participant * Participants with wound infection * Participants assessed to be uncooperative or unable to self-administer the interventions * Participants with known contact allergy to ingredients in the patch formulation (comprising hyaluronic acid, siRNA and glue) and/or isopropyl alcohol * Participants who are unable to personally consent (for e.g., cognitively impaired) |
| Ages | 21 Years to 75 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | National Skin Centre |
| Locations | Singapore, Singapore |
| Start date | 2023-11-14 |
| NCT ID | NCT06138964 |
| Official listing | https://clinicaltrials.gov/study/NCT06138964 |