Comparison of Alpha Blockers (Terazosin and Tamsulosin) in Reducing Ureteral Stent Related
The goal of this clinical trial is to compare how well Terazosin, Tamsulosin and standard care (no alpha-blocker) reduce urinary symptoms after ureteral stent placement. This trial also learn about the safety of these two study medications. Main objective: • To compare how well Terazosin, Tamsulosin and standard of car
| Condition(s) | Stent Related Symptoms |
|---|---|
| Status | Recruiting |
| Phase | Phase 3 |
| Study type | Interventional |
| Summary | The goal of this clinical trial is to compare how well Terazosin, Tamsulosin and standard care (no alpha-blocker) reduce urinary symptoms after ureteral stent placement. This trial also learn about the safety of these two study medications. Main objective: • To compare how well Terazosin, Tamsulosin and standard of care reduce post-stenting urinary symptoms. Secondary objectives: * To compare painkiller use among the groups. * To assess differences in Body pain, General health, Work performance, Sexual matters, and Additional problems using a questionnaire (USSQ). * To assess differences in side effects. After stent placement, subjects will be randomly assigned to one of three groups: 1. Terazosin (alpha-blocker) for 14 days 2. Tamsulosin (alpha-blocker) for 14 days 3. Standard of care (no |
| Who can participate | Inclusion Criteria: 1. Malaysian age 18 years old and above. 2. Able to provide written informed consent to participate in the trial. 3. Willing to comply with study procedures. 4. Unilateral intracorporeal lithotripsy procedure with ureteral stent placement for uncomplicated ureteric or renal calculi Exclusion Criteria: 1. Known comorbidity that increase the risk of complication 1. Prostate pathology: Benign prostate hyperplasia, prostatitis, prostatic carcinoma 2. Bladder pathology: Bladder tumor, stone, overactive bladder 3. Ureteral abnormality/ trauma, urethral stricture 4. Concomitant urinary tract infection 5. Orthostatic hypotension 6. Solitary kidney 2. Previous pelvic/ gynaecological surgery 3. Patient is concomitantly receiving treatment from a pain clinic for chronic pain manag |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Penang Hospital, Malaysia |
| Locations | Alor Star, Kedah, Malaysia; George Town, Pulau Pinang, Malaysia |
| Start date | 2025-06-01 |
| NCT ID | NCT06966804 |
| Official listing | https://clinicaltrials.gov/study/NCT06966804 |