Comparison of Botulinum Toxin Injection and Lateral Internal Sphincterotomy in Chronic Ana
This study aims to compare two commonly used treatments for chronic anal fissure: botulinum toxin injection and lateral internal sphincterotomy. Chronic anal fissure is a painful condition that causes severe discomfort during bowel movements and can significantly affect a patient's quality of life. Botulinum toxin inje
| Condition(s) | Anal Fissure Chronic |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study aims to compare two commonly used treatments for chronic anal fissure: botulinum toxin injection and lateral internal sphincterotomy. Chronic anal fissure is a painful condition that causes severe discomfort during bowel movements and can significantly affect a patient's quality of life. Botulinum toxin injection is a minimally invasive procedure that temporarily relaxes the anal sphincter muscle to promote healing. In contrast, lateral internal sphincterotomy is a minor surgical procedure that permanently reduces sphincter pressure and is considered the standard treatment with high healing rates. A total of 90 adult patients with chronic anal fissure will be enrolled and divided into two groups. One group will receive botulinum toxin injection, while the other group will underg |
| Who can participate | Inclusion Criteria:Age 18-65 years Diagnosed chronic anal fissure (\>6 weeks duration) Failure of conservative management Both male and female patients Willingness to provide informed consent - Exclusion Criteria:Acute anal fissure Previous anal surgery Inflammatory bowel disease Pregnancy Neurological disorders affecting continence Known hypersensitivity to botulinum toxin \- |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | Islamabad Medical and Dental College |
| Locations | Islamabad, Federal, Pakistan |
| Start date | 2026-03-02 |
| NCT ID | NCT07568314 |
| Official listing | https://clinicaltrials.gov/study/NCT07568314 |