Comparison of Cough Response Between Tegilidine and Sufentanil as Pre-induction Agents in
In patients undergoing general anesthesia with planned tracheal intubation , a prospective, randomized, controlled, double-blind study was conducted to record the occurrence of cough 2 minutes after injection of Sufentanil or tegilidine. The cough was graded based on the frequency and duration: Grade I, no cough; Grade
| Condition(s) | General Anesthetic Drug Adverse Reaction |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | In patients undergoing general anesthesia with planned tracheal intubation , a prospective, randomized, controlled, double-blind study was conducted to record the occurrence of cough 2 minutes after injection of Sufentanil or tegilidine. The cough was graded based on the frequency and duration: Grade I, no cough; Grade II, a single mild cough; Grade III, multiple coughs with duration \<1 second; Grade IV, continuous coughing with a duration \>15 seconds. |
| Who can participate | Inclusion Criteria: 1. Age between 18 and 65 years, 18 ≤ BMI (kg/m²) ≤ 30; 2. ASA grade I \~ III; 3. Scheduled elective surgery under general anesthesia with tracheal intubation. Exclusion Criteria: 1. Patients with chronic cough (cough lasting \>8 weeks) or asthma; 2. Patients with a history of allergy to the drugs used during the study; 3. Patients with severe cardiovascular disease, intracranial lesions, eye lesions, or lung lesions. |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | The First People's Hospital of Lianyungang |
| Locations | Lianyungang, Jiangsu, China |
| Start date | 2026-01-15 |
| NCT ID | NCT07323043 |
| Official listing | https://clinicaltrials.gov/study/NCT07323043 |