Comparison of FCV and VCV in One-Lung Ventilation
One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters remain an important clinical concern. Flow-controlled ventilation (FCV) is a newer ventilation
| Condition(s) | One-lung Ventilation (OLV), Thoracic Surgery, Respiratory Mechanics |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters remain an important clinical concern. Flow-controlled ventilation (FCV) is a newer ventilation mode that allows precise control of inspiratory and expiratory flow, potentially improving lung mechanics and gas exchange. Volume-controlled ventilation (VCV) is a widely used conventional ventilation strategy during thoracic anesthesia. The FCVOLVent study is a multicenter, prospective observational study designed to compare the effects of FCV and VCV during one-lung ventilation in adult patients undergoing thoracic surgery. Patients will be ventilated with either FCV or VC |
| Who can participate | Inclusion Criteria Adult patients aged 18 years and older Patients undergoing thoracic surgery requiring one-lung ventilation (OLV) Requirement for one-lung ventilation for at least 30 minutes American Society of Anesthesiologists (ASA) physical status I-III Provision of written informed consent Patients ventilated with flow-controlled ventilation (FCV) or volume-controlled ventilation (VCV) as part of routine clinical practice Exclusion Criteria Requirement for emergency surgery History of untreated asthma High pulmonary risk, defined as predicted postoperative FEV₁ \< 20 mL/kg in males and \< 18 mL/kg in females High cardiac risk, including advanced cardiomyopathy with left ventricular ejection fraction \< 30% Body mass index (BMI) \> 35 kg/m² Contraindication to total intravenous anesth |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Lead sponsor | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital |
| Locations | Ankara, Yenimahalle, Turkey (Türkiye) |
| Start date | 2026-01-01 |
| NCT ID | NCT07392086 |
| Official listing | https://clinicaltrials.gov/study/NCT07392086 |