Complete Revascularization Versus Culprit Lesion Only PCI in NSTEMI
Prospective, randomized, controlled, multicenter, open-label trial to study whether multivessel percutaneous coronary intervention (PCI) is superior over culprit-lesion only PCI in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease.
| Condition(s) | Non-ST-elevation Myocardial Infarction, Multivessel Coronary Artery Disease |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Prospective, randomized, controlled, multicenter, open-label trial to study whether multivessel percutaneous coronary intervention (PCI) is superior over culprit-lesion only PCI in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease. |
| Who can participate | Inclusion Criteria: * NSTEMI as suggested by high-sensitivity troponin algorithms * Multivessel coronary artery disease * Identifiable culprit lesion * Informed consent Exclusion Criteria: * Age \<18 years * Cardiogenic shock * Sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) * Contraindication for coronary revascularization * Prior coronary artery bypass graft * Indication for coronary artery bypass graft surgery * Non-culprit lesion located in the left main coronary artery * Co-morbidity with life expectancy less than 6 months * Type 2 myocardial infarction * Pregnancy and breast feeding period |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Leipzig Heart Science gGmbH |
| Locations | Graz, Austria; Innsbruck, Austria; Vienna, Austria; Bad Berka, Germany; Bad Krozingen, Germany; Bad Nauheim, Germany (+52 more sites) |
| Start date | 2023-10-27 |
| NCT ID | NCT05786131 |
| Official listing | https://clinicaltrials.gov/study/NCT05786131 |