Continuous Glucose Monitoring and OGTT Screen for Cystic Fibrosis Related Diabetes in Cyst
Cystic Fibrosis (CF) related diabetes (CFRD) is a unique form of diabetes mellitus, different from type 1 diabetes and type 2 diabetes. The diagnosis of CFRD is associated with a decline in pulmonary function, decreased nutritional status, and increased mortality. CFRD is extremely common in people with CF, occurring i
| Condition(s) | Cystic Fibrosis-related Diabetes, Cystic Fibrosis |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Cystic Fibrosis (CF) related diabetes (CFRD) is a unique form of diabetes mellitus, different from type 1 diabetes and type 2 diabetes. The diagnosis of CFRD is associated with a decline in pulmonary function, decreased nutritional status, and increased mortality. CFRD is extremely common in people with CF, occurring in approximately 40-50% of adults with CF. Impaired glucose tolerance or dysglycemia is also very common in CF. It is standard of care to screen for CFRD annually from the age of 10 years with a two-hour Oral Glucose Tolerance Test (OGTT) with 75 g dextrose. The gold standard screening for CFRD is the OGTT which is problematic as it is time consuming for patient and staff and adherence to annual screening is low among CF centers. Survival has improved dramatically with the adv |
| Who can participate | Inclusion Criteria: 1. An adult patient, diagnosed with CF, established with Froedtert Multidisciplinary CF Clinic. 2. Normal glucose tolerance or impaired glucose tolerance per OGTT completed in 2024. 3. At healthy baseline status at time of CGM wear and OGTT. Exclusion Criteria: 1. Diagnosed with CFRD and treating with diabetogenic medications. 2. s/p transplant 3. pregnancy 4. failure to wear CGM for entirety of 10 days |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Medical College of Wisconsin |
| Locations | Milwaukee, Wisconsin, United States |
| Start date | 2025-01-13 |
| NCT ID | NCT06560463 |
| Official listing | https://clinicaltrials.gov/study/NCT06560463 |