Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension
INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.
| Condition(s) | Postinduction Hypotension |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients. |
| Who can participate | Inclusion Criteria: We will include consenting patients ≥45 years scheduled for elective major non-cardiac surgery under general anesthesia with planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter and with at least two of the following risk criteria for developing acute kidney injury: * Age ≥65 years * ASA physical status III or IV * Chronic arterial hypertension * Diabetes mellitus requiring medication * Intra-abdominal surgery * Preoperative renal insufficiency (serum creatinine ≥1.2 mg/dL) Exclusion Criteria: * Pregnancy * Cardiac arrhythmia * History of intracranial hemorrhage or intracranial aneurysm * Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary a |
| Ages | 45 Years |
| Sex | All |
| Lead sponsor | Universitätsklinikum Hamburg-Eppendorf |
| Locations | Düsseldorf, Germany; Giessen, Germany; Hamburg, Germany; München, Germany |
| Start date | 2026-05-07 |
| NCT ID | NCT07538388 |
| Official listing | https://clinicaltrials.gov/study/NCT07538388 |