Correlation Between Serum Uric Acid, Serum Homocysteine Level and Interleukin- 17 in Lupus
Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem autoimmune disease characterized by pathogenic autoantibodies production against nuclear structures . SLE affecting mainly women of childbearing age and is characterized by unpredictable flares and remissions. Disease severity varied from a mild e
| Condition(s) | Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem autoimmune disease characterized by pathogenic autoantibodies production against nuclear structures . SLE affecting mainly women of childbearing age and is characterized by unpredictable flares and remissions. Disease severity varied from a mild episodic disorder to a rapidly progressive life-threatening illness. The kidney is the most commonly involved visceral organ in SLE. Therefore, identifying new noninvasive biomarkers of LN severity and outcome is mandatory. IL-17 is a potent pro-infammatory cytokine that amplifes T-cell activation and stimulates fibroblast cells, endothelial, and epithelial cells to produce several pro-infammatory mediators, including IL-1β, IL-6, and TNF-α. IL-17 receptor signaling enhances t |
| Who can participate | Inclusion Criteria: * ● Aged ≥18 years. * SLE patients fulfilling the SLE International Collaborating Clinics (SLICC) classification criteria and matched controls. * Patients cooperative and can answer questions. * Patients who are able and willing to give written informed consent Exclusion Criteria: * ● Individuals with other autoimmune diseases. * Patients receive any hyperuricemia treatment * Pregnancy * Malignancy * Diabetes. * Hypertension. * Heart failure. * Hepatic diseases. * Chronic renal failure other than lupus nephritis. * Renal artery stenosis. * Renal vein thrombosis. * Intrarenal arteriovenous fistula. * Obstructive nephropathy. * Urinary tract obstruction that could affect RI of intra renal arteries. * Uncooperative patients. * Patients not able and willing to give written |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Sohag University |
| Locations | Sohag, Egypt |
| Start date | 2025-01-01 |
| NCT ID | NCT07017868 |
| Official listing | https://clinicaltrials.gov/study/NCT07017868 |