Desflurane vs. Propofol for Cardiac Anesthesia
To investigate whether the inhaled anesthetic desflurane, compared with propofol, exerts cardioprotective effects and reduces the incidence of severe postoperative major cardiac events in patients undergoing coronary artery bypass graft (CABG) surgery.
| Condition(s) | Cardiac Surgery, Coronary Artery Bypass Grafting |
|---|---|
| Status | Recruiting |
| Phase | Phase 3 |
| Study type | Interventional |
| Summary | To investigate whether the inhaled anesthetic desflurane, compared with propofol, exerts cardioprotective effects and reduces the incidence of severe postoperative major cardiac events in patients undergoing coronary artery bypass graft (CABG) surgery. |
| Who can participate | Inclusion Criteria: 1. Patients scheduled for elective coronary artery bypass grafting (CABG) 2. Age ≥ 18 years old; 3. Sign the informed consent form. Exclusion Criteria: 1. Emergency or urgent operation 2. Concomitant valve or aortic surgery 3. History of myocardial infarction in recent 30 days 4. Current use of myocardial preconditioning-affecting medications, such as sulfonylurea (glibenclamide), allopurinol, theophylline, nicorandil(last dose \< 8 hrs), etc 5. Participated in other randomized controlled clinical trials in recent 3 months 6. General anesthesia in recent 30 days 7. History of kidney and liver transplantation, or severe liver and kidney dysfunction (EGFR ≤ 20 mlgmin/1.73 m2, conventional dialysis or patients who have started dialysis; Child Pugh grade C/cirrhosis) 8. His |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Xijing Hospital |
| Locations | Fuzhou, Fujian, China; Cangzhou, Hebei, China; Shijiazhuang, Hebei, China; Shijiazhuang, Hebei, China; Zhengzhou, Henan, China; Wuhan, Hubei, China (+8 more sites) |
| Start date | 2025-10-20 |
| NCT ID | NCT07116733 |
| Official listing | https://clinicaltrials.gov/study/NCT07116733 |