Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary F
This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier.
| Condition(s) | Cancer |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier. |
| Who can participate | Inclusion Criteria: * Individuals who have undergone clinical and/or research genetic evaluation, found to have or not have a germline genetic variant (pathogenic, likely pathogenic, variant of uncertain/unknown significance, likely benign). * Individuals with or without a personal history of malignant or pre-malignant lesions who demonstrate: a) clinical findings suggestive of a genetic cancer susceptibility syndrome including very early age at onset, multiple primary malignancies, or other features; and/or b) family histories suggestive of a genetic cancer susceptibility syndrome, or c) other features suggesting inherited etiology of malignancy as determined by the PI. * Family members of the above participants. Both children (with parental consent as age appropriate) and adults are elig |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Memorial Sloan Kettering Cancer Center |
| Locations | Basking Ridge, New Jersey, United States; Middletown, New Jersey, United States; Montvale, New Jersey, United States; Commack, New York, United States; Harrison, New York, United States; New York, New York, United States (+1 more sites) |
| Start date | 2019-04-17 |
| NCT ID | NCT03922893 |
| Official listing | https://clinicaltrials.gov/study/NCT03922893 |