Discovery and Validation of Periodontitis Biomarkers
Periodontitis is a major public health issue in China: it is responsible for loss of masticatory function in 60 million older adults, and 400-500 million adults are on the same disease trajectory. In addition, gingivitis and early-stage periodontitis are highly prevalent in all age groups. The Lancet 2021 burden of dis
| Condition(s) | Periodontitis, Biomarker in Early Diagnosis, Saliva |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Periodontitis is a major public health issue in China: it is responsible for loss of masticatory function in 60 million older adults, and 400-500 million adults are on the same disease trajectory. In addition, gingivitis and early-stage periodontitis are highly prevalent in all age groups. The Lancet 2021 burden of disease study provides worrying projections for China's oral health, with a 47.8% increase in advanced-stage periodontitis and a 217% increase in edentulism by the year 2050. The numbers are not manageable by the Chinese health system unless a series of coordinated actions are implemented: i) health education promoting oral hygiene in school and the workplace; ii) effective AI-based self-detection strategies and accurate identification of high-risk subjects; iii) efficient treat |
| Who can participate | Inclusion Criteria: 1. Adults between 18 and 40 years of age; 2. Diagnosed with varying degrees of periodontal disease, including gingivitis and stage I periodontitis; 3. Voluntarily agree to participate in the study, have signed the informed consent form, and are able to comply with the study protocol. Exclusion Criteria: 1. Pregnant or breastfeeding women; 2. Individuals who have received antibiotic treatment within the past 3 months; 3. Individuals who have received periodontal treatment (including supragingival scaling) within the past 6 months; 4. Individuals with mucosal or salivary gland diseases (e.g., Sjögren's syndrome); 5. Individuals with severe systemic diseases, immune dysfunction, or health conditions that contraindicate surgery; 6. Individuals who are unwilling to cooperate |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University |
| Locations | Shanghai, Shanghai Municipality, China |
| Start date | 2025-07-21 |
| NCT ID | NCT07293481 |
| Official listing | https://clinicaltrials.gov/study/NCT07293481 |