DNA Methylation and Vascular Function
The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.
| Condition(s) | Obesity, Vascular Dysfunction |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise. |
| Who can participate | Inclusion Criteria: * BMI ≥ 35 kg/m2 * Between ages 18-50 years * Not pregnant * Approved for a bariatric surgery Exclusion Criteria: * To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded * Pregnant women will be excluded, as they will not be eligible for bariatric surgery * Current smokers * Currently abusing alcohol or drugs |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Illinois at Chicago |
| Locations | Chicago, Illinois, United States |
| Start date | 2019-10-11 |
| NCT ID | NCT03527420 |
| Official listing | https://clinicaltrials.gov/study/NCT03527420 |