Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health
This study will evaluate the effects of daily geranylgeraniol (GG) supplementation on muscular strength, body composition, and aerobic capacity in healthy, physically active men and women. Approximately 60 participants aged 30-60 years will be enrolled in a randomized, double-blind, placebo-controlled, parallel-group t
| Condition(s) | Muscle Health, Muscle Strength, Body Composition |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study will evaluate the effects of daily geranylgeraniol (GG) supplementation on muscular strength, body composition, and aerobic capacity in healthy, physically active men and women. Approximately 60 participants aged 30-60 years will be enrolled in a randomized, double-blind, placebo-controlled, parallel-group trial lasting 8 weeks. Participants will be assigned to receive either placebo, 150 mg GG, or 300 mg GG daily. Outcome measures will be assessed at baseline, week 4, and week 8 and include maximal strength (1RM bench press and leg press), fat-free mass, muscular endurance, aerobic capacity (VO2peak), and circulating biomarkers related to metabolism and health. |
| Who can participate | Inclusion Criteria: * Between 30 and 60 years old. * Body mass index values will range from \>18.5 and \<29.9 kg/m2 * Subject agrees to maintain their existing dietary patterns throughout the study period. * Subject agrees to refrain from alcohol, caffeine, and strenuous exercise for 24 hours prior to each test day. * Is physically active, defined as at least 30 min of moderate exercise on at least 4 days a week. * Avoid consumption of pomegranate juice and avoid consumption of CoQ10, vitamin B3 and its precursors, L-carnitine, MK-4 * Subject is willing and able to comply with the study protocol. * Subject has given voluntary, written, informed consent to participate in the study. Exclusion Criteria: * BMI \<18.5 or \> 29.9 kg/m2 * Positive medical history and/or is currently being treated |
| Ages | 30 Years to 60 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Lindenwood University |
| Locations | Saint Charles, Missouri, United States |
| Start date | 2025-03-03 |
| NCT ID | NCT07502924 |
| Official listing | https://clinicaltrials.gov/study/NCT07502924 |