DVT Burden and the Risk of Post-thrombotic Syndrome
Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT), with major consequences for patient quality of life and cost of management. Identifying patients at high risk of developing PTS could be useful for its prevention and may lead to more appropriate therapeutic strategies
| Condition(s) | Postthrombotic Syndrome |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT), with major consequences for patient quality of life and cost of management. Identifying patients at high risk of developing PTS could be useful for its prevention and may lead to more appropriate therapeutic strategies to reduce its incidence and severity. Prognostic tools for predicting risk are very useful for choosing the optimum treatment and improving patient management and are a preliminary step before developing predictive models useful for determining sensitivity to treatment. At present, although several prognostic markers and models have been proposed, it is still difficult to predict who will develop a PTS or a moderate to severe PTS. The development of PTS is multifactorial and |
| Who can participate | Inclusion Criteria: 1. Age ≥ 18 years 2. Patients with symptomatic acute deep venous thrombosis of the lower limbs confirmed by ultrasound on the criteria of venous incompressibility and direct image of the thrombus (patients with stable pulmonary embolism associated with a symptomatic deep venous thrombosis can be included) 3. Affiliates or beneficiaries of a social security scheme. Exclusion Criteria: 1. Pregnant women, women in labour or breastfeeding mothers. 2. Pulmonary embolism haemodynamically unstable defined by systolic blood pressure \< 90 mmHg or a drop in systolic blood pressure of at least 40 mmHg during at least 15 min, shock or cardiac arrest. 3. Asymptomatic venous thrombosis. 4. Symptomatic venous thrombosis of both lower limbs (patients with bilateral deep venous thrombo |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer |
| Locations | Vichy, Allier, France; Carcassonne, Aude, France; Aubagne, Bouches-du-Rhône, France; Marseille, Bouches-du-Rhône, France; Marseille, Bouches-du-Rhône, France; Martigues, Bouches-du-Rhône, France (+21 more sites) |
| Start date | 2024-06-05 |
| NCT ID | NCT06385353 |
| Official listing | https://clinicaltrials.gov/study/NCT06385353 |