Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromis
The goal of this observational study is to investigate how bacterial populations from the intestine and mouth of patients change during the hospitalization period and evaluate if some populations of specific bacteria increase or decrease the risk of acquiring an infection or becoming colonized by pathogenic bacteria. P
| Condition(s) | Antimicrobial Drug Resistance, Antibiotic Resistant Infection, Clostridium Difficile, Carbapenem-Resistant Enterobacteriaceae Infection, Extended Spectrum Beta-Lactamase Producing Bacteria Infection, |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The goal of this observational study is to investigate how bacterial populations from the intestine and mouth of patients change during the hospitalization period and evaluate if some populations of specific bacteria increase or decrease the risk of acquiring an infection or becoming colonized by pathogenic bacteria. Participants will have the following samples collected during enrollment: stool samples (maximum 2x/week), blood draws (1x/week), oral swab (1x/week). |
| Who can participate | Inclusion Criteria: * Admission to an intensive care unit or stem cell transplant unit (for allogeneic stem cell transplantation) within previous 24 hours Exclusion Criteria: * \<18 years of age * Pregnancy * History of inflammatory bowel disease (Crohn's disease, ulcerative colitis) * Gastrointestinal derivation (colostomy, ileostomy, etc.) |
| Ages | 18 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | The Methodist Hospital Research Institute |
| Locations | Houston, Texas, United States; Houston, Texas, United States |
| Start date | 2020-12-08 |
| NCT ID | NCT06258551 |
| Official listing | https://clinicaltrials.gov/study/NCT06258551 |