Early PP Monitored by EIT in Patients With ARDS
Acute Respiratory Distress Syndrome (ARDS) is a syndrome characterized by respiratory distress and refractory hypoxemia caused by pulmonary and extra-pulmonary factors. Despite improvements in diagnosis and treatment in recent years, the mortality rate of severe ARDS is still around 40%. The distribution of lung lesion
| Condition(s) | Acute Respiratory Distress Syndrome |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Acute Respiratory Distress Syndrome (ARDS) is a syndrome characterized by respiratory distress and refractory hypoxemia caused by pulmonary and extra-pulmonary factors. Despite improvements in diagnosis and treatment in recent years, the mortality rate of severe ARDS is still around 40%. The distribution of lung lesions in ARDS patients is significantly gravity-dependent. Even with lung-protective ventilation strategies, tidal volume is concentrated in the ventral lung region, leading to ventilator-associated lung injury. Prone position ventilation can increase ventilation to the dorsal lung tissue and improve the ventilation-perfusion ratio, thus improving oxygenation. During prone position ventilation in ARDS patients, lung-protective ventilation strategies should be maintained, but with |
| Who can participate | Inclusion Criteria: 1. Age ≥ 18 years old； 2. Meets the diagnostic criteria for ARDS according to the 2012 Berlin definition； 3. Intubation with invasive mechanical ventilation time \< 36 hours； 4. PaO2/FiO2 \< 150mmHg. Exclusion Criteria: 1. Contraindication to the prone position; 2. Contraindication to the EIT; 3. Patients have received extracorporeal membrane oxygenation treatment. |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Beijing Chao Yang Hospital |
| Locations | Beijing, Beijing Municipality, China |
| Start date | 2023-05-01 |
| NCT ID | NCT05822869 |
| Official listing | https://clinicaltrials.gov/study/NCT05822869 |