Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally A
This is a prospective, randomized, controlled, multi-center phase III clinical trial that intends to evaluate the role of early cardiovascular intervention based on impedance cardiography in patients with locally advanced non-small cell lung cancer receiving radical radiochemotherapy±immunotherapy.
| Condition(s) | Non-small Cell Lung Cancer, Cardiovascular Complication |
|---|---|
| Status | Recruiting |
| Phase | Phase 3 |
| Study type | Interventional |
| Summary | This is a prospective, randomized, controlled, multi-center phase III clinical trial that intends to evaluate the role of early cardiovascular intervention based on impedance cardiography in patients with locally advanced non-small cell lung cancer receiving radical radiochemotherapy±immunotherapy. |
| Who can participate | Inclusion Criteria: 1. It is diagnosed as non-small cell lung cancer by pathological examination or cytological examination; it is assessed as locally advanced, unresectable stage III non-small cell lung cancer by imaging; 2. Plan to receive radical radiotherapy and chemotherapy ± immunotherapy; 3. Male or female between 18 and 75 years old; 4. Life expectancy ≥ 12 weeks; 5. The World Health Organization (WHO) PS score is 0 or 1; 6. Organ and bone marrow function meet the following conditions: Forced expiratory volume per second (FEV1) ≥1000 ml; absolute neutrophil count ≥1.5×10\^9/L; platelets ≥100×10\^9/L; hemoglobin ≥90 g/L ; Serum creatinine clearance calculated according to the Cockcroft-Gault formula ≥50 mL/min (Cockcroft and Gault 1976); serum bilirubin ≤1.5 times the upper limit of |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Lead sponsor | Sun Yat-sen University |
| Locations | Guangzhou, Guangdong, China |
| Start date | 2021-06-01 |
| NCT ID | NCT04980716 |
| Official listing | https://clinicaltrials.gov/study/NCT04980716 |