EFESO: Study on Juvenile Onset Eosinophilic Fasciitis
Eosinophilic fasciitis is a connective tissue disorder characterized by inflammation of the muscle fasciae, which is very rare in children. In juvenile-onset eosinophilic fasciitis (JEF), there may be severe joint involvement and skin manifestations may be less prevalent than in adults. It represents an important diffe
| Condition(s) | Eosinophilic Fasciitis |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Eosinophilic fasciitis is a connective tissue disorder characterized by inflammation of the muscle fasciae, which is very rare in children. In juvenile-onset eosinophilic fasciitis (JEF), there may be severe joint involvement and skin manifestations may be less prevalent than in adults. It represents an important differential diagnosis of both juvenile-onset systemic sclerosis and localized scleroderma, and the correct classification of these patients is necessary to define a targeted diagnostic-therapeutic pathway. The diagnostic criteria proposed for eosinophilic fasciitis in the adult population do not necessarily require confirmation by skin biopsy, currently the "gold standard," which is an invasive procedure for pediatric patients; however, these criteria have never been directly app |
| Who can participate | Inclusion criterai: All patients diagnosed from 2000 to 31/12/2026 * minimum follow-up 6 months * Age \<18 years at diagnosis; * All patients whose informed consent is collected in accordance with current local legislation will also be considered enrollable. Exclusion Criteria: * Age ≥18 years at diagnosis; * Unwilling to participate into the study; * A follow-up period \< 6 months. |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Meyer Children's Hospital IRCCS |
| Locations | Birmingham, Alabama, United States; Syracuse, New York, United States; Zagreb, Croatia; Hamburg, Germany; Haifa, Israel; Florence, FI, Italy (+9 more sites) |
| Start date | 2025-05-15 |
| NCT ID | NCT07348263 |
| Official listing | https://clinicaltrials.gov/study/NCT07348263 |