Effect of Bariatric Surgery Versus Medical Therapy on Metabolic Syndrome
Bariatric surgery (BS) is known to improve the components of metabolic syndrome (MS) in obese patients. However, few studies have evaluated the impact of bariatric surgery versus medical therapy (MT) in patients with MS, especially in patients with low body mass index (BMI). This study aimed to assess the effect of bar
| Condition(s) | Metabolic Syndrome |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Bariatric surgery (BS) is known to improve the components of metabolic syndrome (MS) in obese patients. However, few studies have evaluated the impact of bariatric surgery versus medical therapy (MT) in patients with MS, especially in patients with low body mass index (BMI). This study aimed to assess the effect of bariatric surgery on MS in patients with low BMI by comparing BS (BMI\<35 kg/m2 and BMI≥35 kg/m2) with MT (BMI\<35 kg/m2). A retrospective study including patients with MS undergoing bariatric surgery and medical therapy at a single institution. We follow up the 5 years effect of bariatric surgery versus medical therapy on the remission of MS, its individual components, atherosclerotic cardiovascular disease (ASCVD) risk, and medication used. |
| Who can participate | 1. Inclusion Criteria: * BMI\<35 kg/m\^2 * Underwent bariatric surgery or medical therapy * Patients met the diagnostic criteria for MS, defined criteria derived from the joint interim statement (JIS) 2. Exclusion Criteria: * Patients who failed to follow up * Insulin dependent diabetes * congenital dementia * brain trauma * epileps * severe hypoglycemic coma * cerebrovascular disease * ischemic * heart disease * renal dysfunction * alcohol abuse * mental illness * psychoactive substance abuse * unwillingness to provide informed consent |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | Third Military Medical University |
| Locations | Chongqing, Chongqing Municipality, China |
| Start date | 2010-05-01 |
| NCT ID | NCT05363059 |
| Official listing | https://clinicaltrials.gov/study/NCT05363059 |