Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
| Condition(s) | Brown Adipose Tissue (BAT) Physiology, Cold Exposure |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration. |
| Who can participate | Inclusion Criteria: * BMI 18.5 to 25 kg/m2 * Able to give informed consent as documented by signature * Moderate caffeine consumption (1 to 3 cups of coffee per day) * Increase of EE in response to mild cold of ≥ 5% of REE Exclusion Criteria: * Known hypersensitivity or allergy to caffeine * Concomitant medication other than prescription free analgesics (paracetamol and NSAID) and oral contraceptives * Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, cardiac arrhythmia, hypertension, diabetes mellitus, hyper- or hypothyroidism) * History of depressive disorder or anxiety disorder * Smoker / habitual tobacco use * Habitual excessive alcohol use * Regular consumption of caffeine containing energy drinks * Weight change |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University Hospital, Basel, Switzerland |
| Locations | Basel, Switzerland |
| Start date | 2026-01-21 |
| NCT ID | NCT06978777 |
| Official listing | https://clinicaltrials.gov/study/NCT06978777 |