Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angio
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors. Previous meta-analyses suggest that ciprofol, a novel intravenous anesthetic agent, may provide improved hemodynamic stability com
| Condition(s) | Intraoperative Hypotension, Ciprofol, Renin-angiotensin System Inhibitors |
|---|---|
| Status | Recruiting |
| Phase | Phase 4 |
| Study type | Interventional |
| Summary | The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors. Previous meta-analyses suggest that ciprofol, a novel intravenous anesthetic agent, may provide improved hemodynamic stability compared to propofol; however, its precise effects on perioperative hemodynamics remain unclear. The study will assess whether ciprofol improves perioperative hemodynamic stability in elderly patients receiving renin-angiotensin system inhibitors. |
| Who can participate | Inclusion Criteria: 1. Patients undergoing elective abdominal surgery under general anesthesia 2. Duration of surgery exceeding 2 hours 3. Patients receiving long-term renin-angiotensin system inhibitor therapy (\>3 months prior to surgery) 4. Age ≥ 65 years 5. ASA classification II-III 6. Informed consent was obtained from patients or their guardians Exclusion Criteria: 1. History of allergy to opioids, propofol, or ciprofol components. 2. Anticipated difficult airway (limited mouth opening, restricted neck movement, or modified Mallampati grade III-IV) or difficult mask ventilation. Body mass index ≤18 or ≥35 kg/m². 3. Severe hepatic dysfunction (total bilirubin ≥3.0 mg/dL or AST/ALT ≥2 times the upper limit of normal). 4. Severe renal impairment (creatinine clearance ≤30 mL/min). 5. Car |
| Ages | 65 Years |
| Sex | All |
| Lead sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Locations | Hangzhou, Zhejiang, China |
| Start date | 2025-04-10 |
| NCT ID | NCT06952608 |
| Official listing | https://clinicaltrials.gov/study/NCT06952608 |