Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And
This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well as postoperative pain. Patients requiring non-surgical root canal retreatment will be rand
| Condition(s) | Persistent Apical Periodontitis |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well as postoperative pain. Patients requiring non-surgical root canal retreatment will be randomly assigned to one of three irrigation concentration groups. Intracanal samples will be collected before and after irrigation to measure neuropeptide levels. Postoperative pain will be assessed using a visual analog scale (VAS) at predetermined time intervals. The results of this study may help clarify the relationship between irrigant concentration, inflammatory mediators, and postoperative pain following root canal retreatment. |
| Who can participate | Inclusion Criteria: * Patients aged between 18 and 65 years. * Systemically healthy individuals (ASA I or II) * Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth * Patients who provide written informed consent. Exclusion Criteria: * Patients with systemic diseases that may affect pain perception or inflammatory response. * Use of analgesics, anti-inflammatory drugs, or antibiotics within 7 days prior to treatment. * Pregnant or lactating women. * Teeth with root fractures, perforations, advanced periodontal disease, or non-restorable teeth. * Teeth with open apices or immature root development. * Presence of acute apical abscess with swelling or sinus tract. * Patients with known allergy to sodium hypochlorite. * Inability to achieve adequate is |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | KEZBAN MELTEM ÇOLAK |
| Locations | Erzurum, Erzurum, Turkey (Türkiye) |
| Start date | 2025-10-01 |
| NCT ID | NCT07453576 |
| Official listing | https://clinicaltrials.gov/study/NCT07453576 |